MovDisordV3, France, Analysis, bibRecord, 000339

Does ageing influence deep brain stimulation outcomes in Parkinson's disease?

Identifieur interne : 000339 ( France/Analysis ); précédent : 000338; suivant : 000340

Does ageing influence deep brain stimulation outcomes in Parkinson's disease?

Auteurs : Fabienne Ory-Magne [France] ; Christine Brefel-Courbon [France] ; Marion Simonetta-Moreau [France] ; Nelly Fabre [France] ; Jean Albert Lotterie [France] ; Patrick Chaynes [France] ; Isabelle Berry [France] ; Yves Lazorthes [France] ; Olivier Rascol [France]

Source :

Movement Disorders [ 0885-3185 ] ; 2007-07-30.

RBID : ISTEX:63A8968FEA436962FC372E504B0D82DCFA1382D7

English descriptors

KwdEn :
- Adult, Aged, Aging, Deep Brain Stimulation (methods), Female, Humans, Male, Middle Aged, Neuropsychological Tests, Parkinson Disease (therapy), Quality of Life, Severity of Illness Index, Statistics, Nonparametric, Treatment Outcome, age, deep brain stimulation, subthalamic nucleus.
MESH :
- methods : Deep Brain Stimulation.
- therapy : Parkinson Disease.
- Adult, Aged, Aging, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Quality of Life, Severity of Illness Index, Statistics, Nonparametric, Treatment Outcome.

Abstract

We sought to define the influence of ageing in clinical, cognitive, and quality‐of‐life outcomes after subthalamic nucleus deep brain stimulation (STN‐DBS) in Parkinson's disease (PD). We performed motor assessment (UPDRS), mood tests, cognitive, and quality of life evaluation (PDQ‐39) on PD patients before surgery, and 12 and 24 months after, and we recorded adverse events. The variations of these parameters after surgery were correlated with age using regression statistical tests. Cerebral bleeding risk was evaluated by a nonparametric test. We enrolled 45 patients (mean age 60 ± 9 years, range 40–73). No significant correlation was found between age and motor scores and PDQ‐39 improvements at 12 months. At 24 months, there was a significant negative correlation between age and the improvement of three dimensions of PDQ 39 (mobility, activities of daily life, and cognition). Cognitive impairment showed no correlation, but apathy and depression were positively correlated with age. Significant statistical difference was observed between cerebral bleeding and age. STN‐DBS is an effective treatment for elderly patients with advanced PD. A longer follow‐up duration and a larger population seem necessary to better assess the quality of life perception in elderly patients and to determinate the real risk of hemorrage. © 2007 Movement Disorder Society

Url:

https://api.istex.fr/document/63A8968FEA436962FC372E504B0D82DCFA1382D7/fulltext/pdf

DOI: 10.1002/mds.21547

Affiliations:

Links to Exploration step

ISTEX:63A8968FEA436962FC372E504B0D82DCFA1382D7

Le document en format XML

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<author><name sortKey="Brefel Ourbon, Christine" sort="Brefel Ourbon, Christine" uniqKey="Brefel Ourbon C" first="Christine" last="Brefel-Courbon">Christine Brefel-Courbon</name>
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<author><name sortKey="Simonetta Oreau, Marion" sort="Simonetta Oreau, Marion" uniqKey="Simonetta Oreau M" first="Marion" last="Simonetta-Moreau">Marion Simonetta-Moreau</name>
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<term>Humans</term>
<term>Male</term>
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<front><div type="abstract" xml:lang="en">We sought to define the influence of ageing in clinical, cognitive, and quality‐of‐life outcomes after subthalamic nucleus deep brain stimulation (STN‐DBS) in Parkinson's disease (PD). We performed motor assessment (UPDRS), mood tests, cognitive, and quality of life evaluation (PDQ‐39) on PD patients before surgery, and 12 and 24 months after, and we recorded adverse events. The variations of these parameters after surgery were correlated with age using regression statistical tests. Cerebral bleeding risk was evaluated by a nonparametric test. We enrolled 45 patients (mean age 60 ± 9 years, range 40–73). No significant correlation was found between age and motor scores and PDQ‐39 improvements at 12 months. At 24 months, there was a significant negative correlation between age and the improvement of three dimensions of PDQ 39 (mobility, activities of daily life, and cognition). Cognitive impairment showed no correlation, but apathy and depression were positively correlated with age. Significant statistical difference was observed between cerebral bleeding and age. STN‐DBS is an effective treatment for elderly patients with advanced PD. A longer follow‐up duration and a larger population seem necessary to better assess the quality of life perception in elderly patients and to determinate the real risk of hemorrage. © 2007 Movement Disorder Society</div>
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Movement Disorders (revue)

Does ageing influence deep brain stimulation outcomes in Parkinson's disease?

Does ageing influence deep brain stimulation outcomes in Parkinson's disease?

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English descriptors

Abstract

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	Movement Disorders (revue)
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